Every SciatiEase ingredient is chosen for a specific role in supporting sciatic nerve health.
SciatiEase isn’t a kitchen-sink formula. Each compound was selected for one of four jobs: calming nerve inflammation, protecting nerves from oxidative damage, supporting nerve repair, or relaxing the muscles that compress the sciatic nerve. Below is the full SciatiEase ingredients list with dosages and the rationale behind each choice.
The cornerstone of SciatiEase. PEA is a fatty-acid amide that occurs naturally in the body and modulates mast-cell activity to calm nerve inflammation at the source. It supports the endocannabinoid system without producing intoxicating effects, and it has been studied extensively in research on chronic nerve pain.
The 600 mg dose in SciatiEase reflects clinically meaningful levels — not the underdosed amounts found in cheaper formulas. This is the difference between a product that works and a product that just lists the ingredient on the label.
R-ALA is the natural, biologically active form of alpha lipoic acid — significantly more bioavailable than the synthetic mixed form. It’s a uniquely versatile antioxidant: it’s soluble in both water and fat, which means it can reach inside nerve tissue (across the blood-nerve barrier) and protect what other antioxidants can’t.
Inside nerve cells, R-ALA neutralizes free radicals, supports mitochondrial energy production, and helps regenerate other antioxidants — key for protecting myelin sheaths and supporting long-term nerve health.
An amino acid that transports fatty acids into mitochondria for energy production. In the context of nerve health, this matters: damaged nerve fibers need ATP to actually rebuild themselves, and Acetyl L-Carnitine delivers the fuel where it’s needed most. It also crosses the blood-brain barrier, supporting both peripheral and central nervous system function.
Standard thiamine (B1) is water-soluble and absorbed poorly. Benfotiamine is the fat-soluble form — it absorbs significantly better and reaches nerve tissue more effectively. It reduces nerve inflammation, supports glucose metabolism in nerve cells, and protects nerves from advanced glycation end-products (AGEs) linked to long-term nerve damage.
Most B12 supplements use cyanocobalamin — a synthetic form your body has to convert before it can use it. SciatiEase uses methylcobalamin, the active, neuro-targeted form. It’s the form your nervous system actually needs to maintain the myelin sheath (the insulating layer around nerves) and support nerve regeneration. For sciatic nerve support, the difference is significant.
Folate and B6 work alongside B12 to handle homocysteine metabolism — an amino acid that, when elevated, is linked to increased nerve and vascular damage. Together, this B-vitamin trio supports myelin maintenance, neurotransmitter synthesis (including serotonin and GABA), and the repair of damaged nerve fibers.
This is the part most sciatica supplements miss. Tight muscles in the lower back, glutes and hips physically compress the sciatic nerve and trigger flare-ups even when inflammation is otherwise controlled. SciatiEase includes four traditional herbs known for muscle and nervous-system calm:
SciatiEase is manufactured in the United States in a facility that is both FDA-registered and GMP-certified. Every batch is tested for purity and potency. The bottle on your doorstep is the same as the bottle the formula was tested with — not a watered-down knock-off.
Take one capsule daily with a meal, or as directed by your healthcare provider. Drink plenty of water. Use consistently for 90–180 days for full nerve-repair benefits. Read more in our How It Works guide.
Buy SciatiEase with up to 70% off only at the official website. All orders backed by a 180-day money-back guarantee. Free shipping on the 6-bottle pack. 2 free bonuses on 3- and 6-bottle orders.
These statements have not been evaluated by the FDA. SciatiEase is not intended to diagnose, treat, cure or prevent any disease. Consult your physician before use, especially if you are pregnant, nursing or taking prescription medication. See our disclaimer for full details.